Isaac Falconer

Research Interests: Functional reorganization of brain networks in post-stroke aphasia. Resting state functional connectivity and predicting language recovery. Dynamic functional network connectivity and neuroplasticity in post-stroke aphasia.

Current Project: MD Project

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Social Media Handle: @issacfalconer

Peer Reviewed Publications:

Marte, M. J., Carpenter, E., Falconer, I. B., Scimeca, M., Abdollahi, F., Peñaloza, C., & Kiran, S. (2022). LEX-BADAT: Language EXperience in Bilinguals With and Without Aphasia DATaset. Frontiers in Psychology, 13(June), 1–6. https://doi.org/10.3389/fpsyg.2022.875928

Abo, K. M., de Aja, J. S., Lindstrom-Vautrin, J., Alysandratos, K. D., Richards, A., Garcia-De-Alba, C., Huang, J., Hix, O. T., Werder, R. B., Bullitt, E., Hinds, A., Falconer, I., Villacorta-Martin, C., Jaenisch, R., Kim, C. F., Kotton, D. N., & Wilson, A. A. (2022). Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell-derived alveolar epithelium. JCI Insight, 7(6). https://doi.org/10.1172/jci.insight.155589

Nichols, P. J., Falconer, I., Griffin, A., Mant, C., Hodges, R., McKnight, C. J., Vögeli, B., & Vugmeyster, L. (2020). Deuteration of nonexchangeable protons on proteins affects their thermal stability, side-chain dynamics, and hydrophobicity. Protein Science, 29(7). https://doi.org/10.1002/pro.3878

Falconer, I. B., Mant, C. T., McKnight, C. J., Vugmeyster, L., & Hodges, R. (2017). Optimized purification of a fusion protein by reversed-phase high performance liquid chromatography informed by the linear solvent strength model. Journal of Chromatography A, 1521. https://doi.org/10.1016/j.chroma.2017.08.080

Vugmeyster, Liliya, Ostrovsky, D., Hoatson, G. L., Qiang, W., & Falconer, I. B. (2017). Solvent-Driven Dynamical Crossover in the Phenylalanine Side-Chain from the Hydrophobic Core of Amyloid Fibrils Detected by 2H NMR Relaxation. Journal of Physical Chemistry B, 121(30). https://doi.org/10.1021/acs.jpcb.7b04726

Vugmeyster, L., Ostrovsky, D., Clark, M. A., Falconer, I. B., Hoatson, G. L., & Qiang, W. (2016). Fast Motions of Key Methyl Groups in Amyloid-β Fibrils. Biophysical Journal, 111(10). https://doi.org/10.1016/j.bpj.2016.10.001 Vugmeyster, Liliya, Clark, M. A., Falconer, I. B., Ostrovsky, D., Gantz, D., Qiang, W., & Hoatson, G. L. (2016). Flexibility and solvation of amyloid-β hydrophobic core. Journal of Biological Chemistry, 291(35), 18484–18495. https://doi.org/10.1074/jbc.M116.740530

 

Conference Presentations:

Falconer, I. B., Varkanitsa, M., & Kiran, S. People with post-stroke aphasia have reduced temporal variability of functional connectivity in the language network compared to healthy controls. 60th Annual Academy of Aphasia Meeting. 2022. Philadelphia, PA

Falconer, I., Varkanitsa, M., & Kiran, S. Dynamic resting state functional connectivity predicts treatment response in people with post-stroke aphasia. Organization for Human Brain Mapping. 2022. Glasgow, UK

Falconer, I., Varkanitsa, M., & Kiran, S. (2021). Pre-treatment graph measures of resting-state functional connectivity predict language treatment outcome in aphasia. Society for the Neurobiology of Language. 2021 (virtual). https://www.neurolang.org/programs/SNL_2021_Program.pdf

 

Awards and Recognition:

2023 NIDCD Research Symposium in Clinical Aphasiology Fellowship