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- ENG BE 200: Introduction to Probability
An introductory course designed for sophomore engineering students that introduces the fundamentals of probability and statistics without the use of transforms. Coverage includes descriptive statistics, basics of probability theory, multiple random variables, expectation, Markov chains, and statistical testing. Computer simulations of probabilistic systems are included. Examples are taken from engineering systems. This course cannot be taken for credit in addition to ENG SC 381. - ENG BE 209: Principles of Molecular Cell Biology and Biotechnology
Introduction to the molecular, physical and computational principles of cell function in the context of cutting-edge applications in bioengineering and medicine. Biological concepts include: molecular building blocks, energetics, transport, metabolism, nucleic acids, gene expression and genetics. Applications include bioenergy, synthetic biology, the human genome project, and gene circuit engineering. Labs will teach fundamental techniques of molecular biology including a multi-week module where students build and quantify bacterial gene expression system. Labs emphasize the experimental, problem solving, and analytical skills required in modern engineering and research. - ENG BE 401: Signals and Systems in Biomedical Engineering
Signals and systems with an emphasis on application to biomedical problems. Laplace transforms, Fourier series, Fourier integral, convolution and the response of linear systems, frequency response, and Bode diagrams. Introduction to communication systems, multiplexing, amplitude modulation, and sampling theorem. Cannot be taken for credit in addition to ENG SC 401. - ENG BE 402: Control Systems in Biomedical Engineering
Mathematical analysis of dynamic and linear feedback control systems. Emphasis on application to physiological systems, physiological transport, pharmacokinetics, glucose/insulin control, and respiratory control. Performance criteria. Root locus, Nyquist, and other stability criteria. State space analysis with state variable feedback control. Design and compensation. Cannot be taken for credit in addition to ENG SC 402. - ENG BE 420: Introduction to Solid Biomechanics
Introductory course to mechanics of solid elastic continua. Basics of vector and tensor algebra and calculus; kinematics of deformation, stress analysis, constitutive equations, finite elasticity; linear elasticity; virtual work; the Ritz approximation. In addition to the classical Hookean elasticity, finite deformation theory is presented to describe mechanical behavior of biological soft tissues and cells. Illustrative examples from tissue and cell biomechanics. Design elements will be included in problems and examples. - ENG BE 436: Fundamentals of Fluid Mechanics
Introductory course emphasizing the application of the principles of conservation of mass, momentum, and energy to fluid systems. - ENG BE 451: Directed Study in Biomedical Engineering
Individual study of a topic in biomedical engineering not covered in a regularly scheduled course. A faculty member must agree to supervise the study before registration. Term paper and/or written examination. - ENG BE 465: Biomedical Engineering Senior Project
Selection of project and project supervisor must be approved by course instructor. Project is in an area of biomedical engineering, such as biomedical instrumentation, biosensors, tissue engineering, biological signal processing, biological modeling and simulation, clinical imaging or informational systems, etc.Projects will be conducted by teams of two or three students, and projects must include significant design experience. Research of background, planning and initial work on senior design project. Guidance in performing and presenting (in written and oral form) a technical project proposal. Skills in proposal writing, oral presentation techniques. Formal proposal must be approved by technical advisor. 2 cr. - ENG BE 466: Biomedical Engineering Senior Project
Completion of project in an area of biomedical engineering. Expanded training in technical project presentation techniques. Includes writing of progress reports, abstracts, final reports. Course culminates with an oral presentation at annual Senior Project Conference. Written final report must be approved by the faculty. 4 cr. - ENG BE 467: Design, Development, Marketing, and Entrepreneurship in Biomedical Engineering
A combined academic and industry taught course educating students on project definition, and on the design, development, and technology transfer of potential biomedical products in the context of the student's major capstone project. Students will learn from faculty and industry lecturers the best practices for medical device development including: product development via design and process control, intellectual property and innovation in biomedical engineering including patents, and clinical regulatory issues including clinical trial design. School of Management faculty will emphasize marketing, technology transfer and entrepreneurship for bioengineering products. Case study examples will be provided. ENG BE 465 must be taken concurrently. 2 cr. - ENG BE 491: Engineering Physiology Laboratory I
Laboratory course designed to develop experimental and modeling skills. Simulation of physical and physiological systems, experimental determination of transfer functions, filtering properties of systems, transducer instrumentation, muscle dynamics, and spectral analysis. Emphasis is on comparison of experimental data with theoretical expectation. - ENG BE 492: Engineering Physiology Laboratory II
Laboratory course designed to develop research skills including data acquisition with instruments used in physiology and biology such as optical microscopes, ultrasound transducers, as well as air pressure and flow transducers. Emphasis is on data acquisition, quantitative analysis, physiological interpretation and written presentation in the form of professional quality reports. 2 cr. - ENG BE 500: Special Topics in Biomedical Engineering
Specific prerequisites vary according to topic. Coverage of a specific topic in biomedical engineering. One topic covered in depth each semester offered. Subject matter varies from year to year. - ENG BE 505: Molecular Bioengineering I
Provides engineering perspectives on the building blocks of living cells and materials for biotechnology. Focuses on origins and synthesis in life and the laboratory, including biological pathways for sythesis of DNA, RNA and proteins; transduction, transmission, storage and retrieval of biological informatin by macromoleclues; polyerase chain reaction, restriction enzymes, DNA sequencing; energetics of protein folding and trafficking; mechanisms of enzymatic catalysts and receptor-ligand binding; cooperative proteins, multi-protein complexes and control of metabolic pathways; generation, storage, transmission and release of biomolecular energy; and methods for study and manipulation of molecules which will include isolation, purification, detection, chemical characterization, imaging and visualization of structure. - ENG BE 506: Physical Chemistry of Cell Structure and Machinery
Building on the engineering perspective of molecular-cell biology presented in ENG BE 505, the objective of this course is to provide a basic understanding of the physical chemistry of molecular structures important in living cells and in technological applications. Topics include: noncovalent interactions of biomolecules in water, thermodynamics of solutions and phase mixtures; nonequilibrium kinetics; polymer physics and elasticity; lipid self-assembly and interfacial thermodynamics; biomembranes; adhesion and molecular bonding; chemical grafting and surface analysis. - ENG BE 508: Quantitative Studies of the Respiratory and Cardiovascular Systems
The quantitative physiological aspects of the respiratory and cardiovascular systems are studied. Classical models of these systems are considered including lumped element models, branching tree structures, and distributed parameter models to predict wave propagation in compliant walled tubes filled with compressible or incompressible fluids. Extensive computer models are developed to simulate the behavior of these systems in the frequency and time domains. Includes lab. - ENG BE 509: Quantitative Physiology of the Auditory System
Introduction to the mammalian auditory system from a systems prospective. The class follows how sound propagates into the ear, how mechanical energy is transformed into a neural code, how that code is transformed through the mammalian auditory pathway from the cochlea to the cortex, and how auditory sensation and perception are related to this chain of neural processing. Anatomy and physiology will cover the structure and function of the middle ear, cochlea, brainstem, midbrain, thalamus, and cortex. Perceptual topics include basic sensitivity, spatial hearing, pitch perception, auditory scene analysis, attention, and speech perception. Implications for hearing impairment and prosthetic hearing devices will be covered. Associated discussion sessions cover recent research findings from general-interest, high-impact publications. 4 cr. - ENG BE 511: Biomedical Instrumentation
Physiological signals, origin of biopotentials (ECG, EMG, EEG), biomedical transducers and electrodes. Biomedical signal detection, amplifications and filtering. Analog front-ends of biomedical instruments. Electrical safety in medical environment. Laboratory experiments supplement lectures. - ENG BE 512: Biomedical Instrument Design
An introduction to techniques for the design of biomedical instrumentation including sensors and their associated electronics. Mathematical models for a wide variety of sensors ranging from resistive sensors to biosensors are reviewed along with the resulting implications for the design of signal-conditioning electronics. A case-study approach is used in which specific sensor systems are evaluated for sensitivity, selectivity, dynamic range, response time, and reproducibility. Includes lab. - ENG BE 513: Biological and Environmental Acoustics
Application of acoustics to biological and environmental research. Introduction to physical acoustics with examples from actual terrestrial and marine environments. The use of sound by animals for communication and echolocation. Application of acoustics to conservation biology.
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